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Sample questions / Reproductive

Organ system

Reproductive questions for Step 1

Work through reproductive vignettes that mix physiology, pathology and pharmacology, the way the exam does. Every explanation covers all five options.

MicrobiologyEasy

Mumps orchitis

An incompletely vaccinated 8-year-old boy has fever and swollen parotid glands after contact with a classmate with the same illness.

Which complication is most common in males past puberty?

  1. Pancreatitis
  2. Orchitis
  3. Deafness
  4. Meningitis
  5. Myocarditis
GeneticsEasy

Limits of cell-free DNA testing

At 12 weeks, a 32-year-old woman's cell-free DNA test shows high risk for trisomy 21. She asks if this confirms Down syndrome.

Which statement about this screening test is correct?

  1. It cannot determine fetal sex
  2. Requires amniocentesis confirmation of positive results
  3. It can be performed only after 20 weeks gestation
  4. It has a 50% false positive rate
  5. It only detects trisomy 21 and no other aneuploidies
PharmacologyEasy

Trichomonas treatment

A 35-year-old woman has had frothy green vaginal discharge and itching for 3 days, with mild dysuria. Her cervix is red with punctate hemorrhages, and a wet mount shows motile flagellated protozoa. She recently took antibiotics for a UTI and has one sexual partner.

What is the treatment of choice?

  1. Metronidazole
  2. Acyclovir
  3. Doxycycline
  4. Fluconazole
  5. Azithromycin
BiochemistryMedium

Balanced translocation miscarriage

A 28-year-old woman has had several pregnancy losses. Karyotype shows a balanced translocation.

Which meiotic event explains the losses?

  1. Sister chromatid separation
  2. Crossing over
  3. Polar body extrusion
  4. Nondisjunction
  5. Unbalanced segregation
PathologyMedium

Mediastinal chorio

A 28-year-old man has an anterior mediastinal mass and breast growth. Beta-hCG is high and AFP is normal. Biopsy shows bloody tissue with cytotrophoblasts and syncytiotrophoblasts.

What is the diagnosis?

  1. Choriocarcinoma
  2. Mature teratoma
  3. Seminoma
  4. Yolk sac tumor
  5. Embryonal carcinoma

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