Sample questions / Reproductive
Organ system
Reproductive questions for Step 1
Work through reproductive vignettes that mix physiology, pathology and pharmacology, the way the exam does. Every explanation covers all five options.
MicrobiologyEasy
Mumps orchitis
An incompletely vaccinated 8-year-old boy has fever and swollen parotid glands after contact with a classmate with the same illness.
Which complication is most common in males past puberty?
- Pancreatitis
- Orchitis
- Deafness
- Meningitis
- Myocarditis
GeneticsEasy
Limits of cell-free DNA testing
At 12 weeks, a 32-year-old woman's cell-free DNA test shows high risk for trisomy 21. She asks if this confirms Down syndrome.
Which statement about this screening test is correct?
- It cannot determine fetal sex
- Requires amniocentesis confirmation of positive results
- It can be performed only after 20 weeks gestation
- It has a 50% false positive rate
- It only detects trisomy 21 and no other aneuploidies
PharmacologyEasy
Trichomonas treatment
A 35-year-old woman has had frothy green vaginal discharge and itching for 3 days, with mild dysuria. Her cervix is red with punctate hemorrhages, and a wet mount shows motile flagellated protozoa. She recently took antibiotics for a UTI and has one sexual partner.
What is the treatment of choice?
- Metronidazole
- Acyclovir
- Doxycycline
- Fluconazole
- Azithromycin
BiochemistryMedium
Balanced translocation miscarriage
A 28-year-old woman has had several pregnancy losses. Karyotype shows a balanced translocation.
Which meiotic event explains the losses?
- Sister chromatid separation
- Crossing over
- Polar body extrusion
- Nondisjunction
- Unbalanced segregation
PathologyMedium
Mediastinal chorio
A 28-year-old man has an anterior mediastinal mass and breast growth. Beta-hCG is high and AFP is normal. Biopsy shows bloody tissue with cytotrophoblasts and syncytiotrophoblasts.
What is the diagnosis?
- Choriocarcinoma
- Mature teratoma
- Seminoma
- Yolk sac tumor
- Embryonal carcinoma
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